Describe the site of action for angina pectoris& how nitroglycerin beta blockers & calcium work@ cellular leve?
May 30th, 2010 by admin
Beta blockers reduce the workload on the heart, which reduces the force of the heart muscle contraction. This reduces the amount of oxygen that is required by the heart muscle and this reduces ischemia.
Ca channel blockers relax the coronary arteries and blood vessels and also lessen the force of the contraction of the heart.
Nitrates relax and dilate blood vessels which allows more blood to flow to the heart and reduces it’s workload.
Posted in angina pectoris
May 30th, 2010 at 7:08 pm
Have you tried looking at Wikipedia for info? I know sometimes it’s fairly innacurate, but if you read it, you might be get the info you need.
References :
May 30th, 2010 at 7:54 pm
Angina Pectoris – literally means "choking pain," and angina pectoris refers to a painful or uncomfortable sensation in the chest that occurs when part of the heart does not receive enough oxygen due to disease in the coronary arteries that supply blood to the heart.
The coronary arteries supply the heart muscle with oxygen and nutrients. The word "coronary" means a crown and is the name given to the arteries that circle the heart like a crown.
Coronary artery disease (CAD) is the most common form of heart disease.
Coronary heart disease develops when one or more of the coronary arteries that supply the blood to the heart become narrower than they used to be, due to the buildup of cholesterol and other substances in the wall of the artery, affecting the blood flow to the heart muscle. Without an adequate blood supply, heart muscle tissue can be damaged.
Deposits of cholesterol and other fat-like substances can build up in the inner lining of these blood vessels and become coated with scar tissue, forming a cholesterol-rich bump in the blood vessel wall known as plaque. Plaque buildup narrows and hardens the blood vessel, a process called atherosclerosis, or hardening of the arteries.
Treatments by -
Nitroglycerin: Nitroglycerin is a sublingual (under the tongue) medication relieves angina symptoms by expanding blood vessels and decreasing the muscle’s need for oxygen. This allows more blood to flow through the coronary arteries. Nitroglycerin is taken only when the patient actually has symptoms or expect to have them. Slow – or long-acting nitroglycerin can be used as a preventative treatment for angina but not until beta blockers are tried first.
Beta blockers: Beta blockers lessen the heart’s workload. They slow the heart rate, decrease blood pressure, and lessen the force of contraction of the heart muscle. This decreases the heart’s need for oxygen and thus decreases angina symptoms. Beta blockers are taken every day, regardless of whether the patient is having symptoms, because they are proven to prevent heart attacks and sudden death.
Calcium channel blockers (CCBs): Calcium channel blockers are used primarily when beta blockers cannot be used and/or the patient is still having angina with beta blockers. Calcium channel blockers also lower blood pressure and certain ones slow heart rate. Calcium channel blockers have to be taken every day.-
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May 30th, 2010 at 8:04 pm
Beta blockers reduce the workload on the heart, which reduces the force of the heart muscle contraction. This reduces the amount of oxygen that is required by the heart muscle and this reduces ischemia.
Ca channel blockers relax the coronary arteries and blood vessels and also lessen the force of the contraction of the heart.
Nitrates relax and dilate blood vessels which allows more blood to flow to the heart and reduces it’s workload.
References :
Cardiac Nurse
May 30th, 2010 at 8:30 pm
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